1. PROTAC
  2. Ligand for E3 Ligase
  3. VL285

VL285 

Cat. No.: HY-111663
Handling Instructions

VL285 is a potent VHL ligand.

For research use only. We do not sell to patients.

VL285 Chemical Structure

VL285 Chemical Structure

CAS No. : 1448188-57-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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Description

VL285 is a potent VHL ligand.

IC50 & Target

VHL[1]

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (234.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8774 mL 9.3870 mL 18.7741 mL
5 mM 0.3755 mL 1.8774 mL 3.7548 mL
10 mM 0.1877 mL 0.9387 mL 1.8774 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.91 mM); Clear solution

References
Molecular Weight

532.65

Formula

C₂₉H₃₂N₄O₄S

CAS No.

1448188-57-5

SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
VL285
Cat. No.:
HY-111663
Quantity:

VL285

Cat. No.: HY-111663