Mal-amido-PEG4-NHS ester

Name: Mal-amido-PEG4-NHS ester
Brand: MedChemExpress
SKU: HY-W040134
Rating: 4.5 (1 reviews)

Cat. No.: HY-W040134 Purity: 99.18%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG4-NHS ester Chemical Structure

CAS No. : 756525-99-2

Size	Price	Stock	Quantity
100 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
1 g	USD 255	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

513.50

Formula

C₂₂H₃₁N₃O₁₁

CAS No.

756525-99-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (194.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9474 mL	9.7371 mL	19.4742 mL
5 mM	0.3895 mL	1.9474 mL	3.8948 mL
10 mM	0.1947 mL	0.9737 mL	1.9474 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.18%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (243 KB) HNMR (278 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9474 mL	9.7371 mL	19.4742 mL	48.6855 mL
	5 mM	0.3895 mL	1.9474 mL	3.8948 mL	9.7371 mL
	10 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	15 mM	0.1298 mL	0.6491 mL	1.2983 mL	3.2457 mL
	20 mM	0.0974 mL	0.4869 mL	0.9737 mL	2.4343 mL
	25 mM	0.0779 mL	0.3895 mL	0.7790 mL	1.9474 mL
	30 mM	0.0649 mL	0.3246 mL	0.6491 mL	1.6228 mL
	40 mM	0.0487 mL	0.2434 mL	0.4869 mL	1.2171 mL
	50 mM	0.0389 mL	0.1947 mL	0.3895 mL	0.9737 mL
	60 mM	0.0325 mL	0.1623 mL	0.3246 mL	0.8114 mL
	80 mM	0.0243 mL	0.1217 mL	0.2434 mL	0.6086 mL
	100 mM	0.0195 mL	0.0974 mL	0.1947 mL	0.4869 mL