1448189-80-7
1448189-80-7
Chemical Structure
(S,R,S)-AHPC monohydrochloride
Synonym(s): VH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride
- CAS No.: 1448189-80-7
- Formula:C22H31ClN4O3S
- Molecular Weight:467.02
IUPAC Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChIKey: JYRTWGCWUBURGU-MSSRUXLCSA-N
SMILES: O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Biological Activity: (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1][2][3].
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(S,R,S)-AHPC monohydrochloride | 99.83% | (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. | ||||||||||||||||||||
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(S,R,S)-AHPC monohydrochloride (Standard) | ≥98% | (S,R,S)-AHPC monohydrochloride (Standard) (VH032-NH2 monohydrochloride (Standard)) is the analytical standard of (S,R,S)-AHPC monohydrochloride (HY-101763A). This product is intended for research and analytical applications. (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. | ||||||||||||||||||||
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References
- [1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7. [Content Brief]
- [2]. Krieger J, et al. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. ChemMedChem. 2023 Apr 17;18(8):e202200615. [Content Brief]
- [3]. Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers[J]. J Med Chem. 2023 Sep 28;66(18):12776-12811. [Content Brief]
