Pomalidomide-C6-COOH

Cat. No.: HY-131887 Purity: 98.02%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide-C6-COOH is the pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC.

For research use only. We do not sell to patients.

Pomalidomide-C6-COOH Chemical Structure

CAS No. : 2225940-50-9

Size	Price	Stock	Quantity
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Pomalidomide-C6-COOH is the pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC^[1].

Molecular Weight

401.41

Formula

C₂₀H₂₃N₃O₆

CAS No.

2225940-50-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (311.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4912 mL	12.4561 mL	24.9122 mL
5 mM	0.4982 mL	2.4912 mL	4.9824 mL
10 mM	0.2491 mL	1.2456 mL	2.4912 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.02%

Select Batch:

Data Sheet (271 KB) SDS (418 KB)

COA (252 KB) HNMR (270 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Xiaojuan Qu, et al. Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. Eur J Med Chem. 2021. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4912 mL	12.4561 mL	24.9122 mL	62.2805 mL
	5 mM	0.4982 mL	2.4912 mL	4.9824 mL	12.4561 mL
	10 mM	0.2491 mL	1.2456 mL	2.4912 mL	6.2280 mL
	15 mM	0.1661 mL	0.8304 mL	1.6608 mL	4.1520 mL
	20 mM	0.1246 mL	0.6228 mL	1.2456 mL	3.1140 mL
	25 mM	0.0996 mL	0.4982 mL	0.9965 mL	2.4912 mL
	30 mM	0.0830 mL	0.4152 mL	0.8304 mL	2.0760 mL
	40 mM	0.0623 mL	0.3114 mL	0.6228 mL	1.5570 mL
	50 mM	0.0498 mL	0.2491 mL	0.4982 mL	1.2456 mL
	60 mM	0.0415 mL	0.2076 mL	0.4152 mL	1.0380 mL
	80 mM	0.0311 mL	0.1557 mL	0.3114 mL	0.7785 mL
	100 mM	0.0249 mL	0.1246 mL	0.2491 mL	0.6228 mL