HER3 Protein, Rat (HEK293, Fc)

HER3 is a tyrosine-protein kinase that is a key cell surface receptor for neuregulin. ErbB2 and ErbB3 can form dimers and activate signaling pathways including MAPK, PI3K/Akt and PLC纬 to promote tumor development. HER3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER3 Protein, Rat (HEK293, Fc) is 622 a.a., with molecular weight of ~115 kDa.

HER3 is a tyrosine protein-kinase that is a key cell surface receptor for neuregulin. Under the activation of neuregulin 1 (NRG1), ligand binding enhances the phosphorylation of tyrosine residues and facilitates their interaction with PI3K/p85. HER3 is involved in the regulation of myeloid differentiation and plays a key role in the cellular process of normal development and function. ErbB2 and ErbB3 can form dimers and activate signaling pathways including MAPK, PI3K/Akt and PLCγ to promote tumor development^[1][2][3][4].

Rat

HEK293

C-hFc

G3V6N1 (S20-H641)

29496  [NCBI]

Approximately 115 kDa

Greater than 80% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.