Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Also Known as nuc-ErbB3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29496

About Erbb3

Primary_assembly 7: 996,225-1,015,525 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 280 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Kidney (RPKM 239.), Liver (RPKM 25.8) and 7 other tissues.

Summary

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to Insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products (1)

mRNA Protein Name
NM_017218.3 NP_058914.2 receptor tyrosine-protein kinase erbB-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuregulin binding IMP
IMP: Inferred from mutant phenotype
14711829 RGD
enables neuregulin receptor activity IMP
IMP: Inferred from mutant phenotype
14711829 RGD
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IEP
IEP: Inferred from expression pattern
9030624 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9389501 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
30813222 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12454858 RGD
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14711829 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
10653587 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
14711829 RGD
involved in positive regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
30813222 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18184445 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
8846777 RGD
involved in tongue development IEP
IEP: Inferred from expression pattern
10908606 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16859650 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
7589796 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb3 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (55 - 166)

Furin-like

Furin-like: pfam00757 (181 - 328)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 473)

GF_recep_IV

GF_recep_IV: pfam14843 (498 - 629)

TM_ErbB3

TM_ErbB3: cd12095 (637 - 673)

PKc_like

PKc_like: cl21453 (698 - 976)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1339 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-3

  • avian erythroblastosis oncogene B 3

  • c-erbB-3

  • c-erbB3

  • proto-oncogene-like protein c-ErbB-3

  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Recombinant Erbb3 Proteins

Cat. No. Product Name Accession Purity
HY-P74892 HER3 Protein, Rat (HEK293, Fc) G3V6N1 (S20-H641) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0426A Olopatadine hydrochloride 99.83% Unkown
HY-W062109 Olopatadine 98.94% Unkown
HY-B0426AR Olopatadine hydrochloride (Standard) / Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-118998 TX2-121-1 Inhibitor / Phase 3
HY-13050 Sapitinib Inhibitor 99.93% Phase 2
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99275 Patritumab Inhibitor 99.28% Phase 3
HY-P99672 Istiratumab Inhibitor 98.45% Phase 2
HY-P991240 CDX-3379 Inhibitor 99.38% Phase 2
HY-P991524 MM-111 Inhibitor / Phase 2
HY-P99304 Lumretuzumab Inhibitor ≥99.0% Phase 1
HY-P991244 REGN-1400 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100848 TX1-85-1 Inhibitor 99.65% Unkown
HY-168438 ERBB agonist-1 99.16% Unkown
HY-18609 PD158780 Inhibitor 99.47% Unkown
HY-E70715 ERBB2 775YVMA776 Recombinant Human Active Protein Kinase / Unkown
HY-13050A Sapitinib fumarate Inhibitor / Unkown
HY-B0426AS2 Olopatadine-d6 hydrochloride / Unkown
HY-RS04469 ERBB3 Human Pre-designed siRNA Set A / Unkown
HY-RS04470 Erbb3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04471 Erbb3 Rat Pre-designed siRNA Set A / Unkown
HY-W062109S Olopatadine-d6 / Unkown
HY-B0426AS Olopatadine-d3 hydrochloride / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991159 Ruzaltatug Inhibitor 95.69% Unkown
HY-P992128 Rinumafusp alfa Inhibitor 97.09% Unkown
HY-P991241 Anti-ERBB3/HER3 (29Z6) Inhibitor / Unkown
HY-P991243 MP-RM-1 Inhibitor 96.29% Unkown
HY-P991245 Anti-ERBB3/HER3 (SGP1) Inhibitor / Unkown
HY-P991983 DB-1310 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb3 NCBI NCBI:2065