2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. EGFR Akt
  4. MP-RM-1

MP-RM-1 is an antibody-based, non-competitive ErbB-3 inhibitor with a Kd value of 32.7 nM. MP-RM-1 inhibits both ligand-dependent and ligand-independent ErbB-3 activation, blocks ErbB-2/ErbB-3 heterodimerization, induces ErbB-3 internalization and degradation, and suppresses the phosphorylation of downstream Akt. MP-RM-1 exerts its antagonistic effect through a non-competitive mechanism. MP-RM-1 inhibits tumor growth in melanoma and prostate cancer xenograft models in nude mice and reduces the proliferative activity of tumor cells.

For research use only. We do not sell to patients.

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Based on 1 publication(s) in Google Scholar

MP-RM-1 Related Antibodies

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Description

MP-RM-1 is an antibody-based, non-competitive ErbB-3 inhibitor with a Kd value of 32.7 nM. MP-RM-1 inhibits both ligand-dependent and ligand-independent ErbB-3 activation, blocks ErbB-2/ErbB-3 heterodimerization, induces ErbB-3 internalization and degradation, and suppresses the phosphorylation of downstream Akt. MP-RM-1 exerts its antagonistic effect through a non-competitive mechanism. MP-RM-1 inhibits tumor growth in melanoma and prostate cancer xenograft models in nude mice and reduces the proliferative activity of tumor cells[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1]

ErbB3

32.7 nM (Kd)

In Vitro

MP-RM-1 (0.01-10 μg/mL; 15-120 min) inhibits NRG-1β-dependent phosphorylation of ErbB-3 and Akt in a dose- and time-dependent manner in breast cancer cells MDA-MB-435 and melanoma cells IR-8[1].
MP-RM-1 (10 μg/mL) significantly inhibits the colony-forming ability of IR-8 melanoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MP-RM-1 Related Antibodies
In Vivo

MP-RM-1 (20 mg/kg; i.p.; twice weekly) significantly inhibits the growth of ErbB-3 melanoma xenografts in nude mice, and reduces ErbB-3 expression and Akt phosphorylation levels in tumor tissues[1].
MP-RM-1 (20 mg/kg; i.p.; twice weekly) significantly inhibits the growth of DU-145 prostate cancer xenografts in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 nu/nu (7-weeks old, melanoma xenograft via subcutaneous injection of IR-8 cells)[1]
Dosage: 20 mg/kg (tumor growth delay); 20 mg/kg (tissue analysis)
Administration: i.p.; twice weekly (tumor growth delay); i.p.; single injection (tissue analysis)
Result: Caused significant tumor growth delay over 8 weeks.
Reduced ErbB-3 expression and Akt phosphorylation significantly compared to controls.
Decreased Ki-67 staining index to 35.8 vs 57.9 in controls (P = 0.048).
Decreased mitotic index to 6.6 vs 9.5 in controls (P = 0.017).
Animal Model: CD-1 nu/nu (7-weeks old, prostate cancer xenograft via subcutaneous injection of DU-145 cells)[1]
Dosage: 20 mg/kg
Administration: i.p.; twice weekly
Result: Caused significant tumor growth delay over 4 weeks.
Induced statistically significant differences in tumor volume relative to controls at multiple time points.
Gene ID

2065  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

147.86 kDa

Appearance

Liquid

Color

Colorless to off-white

SMILES

N/A
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized huHER3-Fc can bind MP-RM-1. The EC50 for this effect is 19.07 ng/mL.
Purity & Documentation
References
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MP-RM-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MP-RM-1EGFRAktEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BNRG-1βhuman breast cancer cellsErbB-2human gastric cancer cellshuman prostate cancer cellsHER-3human melanoma cellsErbB-3METInhibitorinhibitorinhibit

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