1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. TX1-85-1

TX1-85-1 

Cat. No.: HY-100848 Purity: >98.0%
Handling Instructions

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM and is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

For research use only. We do not sell to patients.

TX1-85-1 Chemical Structure

TX1-85-1 Chemical Structure

CAS No. : 1603845-32-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 243 In-stock
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 340 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM and is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].

IC50 & Target[1]

ErbB3

23 nM (IC50)

In Vitro

TX1-85-1 possesses an anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

580.68

Formula

C₃₂H₃₆N₈O₃

CAS No.

1603845-32-4

SMILES

CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
TX1-85-1
Cat. No.:
HY-100848
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TX1-85-1

Cat. No.: HY-100848