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  6. HER3 Protein, Mouse (HEK293, His)

HER3 Protein, Mouse (HEK293, His)

Cat. No.: HY-P70857
Handling Instructions

HER3 Protein, a vital tyrosine-protein kinase and neuregulin cell surface receptor, activates upon binding to neuregulin-1 (NRG1), enhancing phosphorylation on tyrosine residues and associating with the p85 subunit of phosphatidylinositol 3-kinase. It is also activated by CSPG5 and plays a crucial role in regulating myeloid cell differentiation. HER3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HER3 Protein, Mouse (HEK293, His) is 622 a.a., with molecular weight of 90-120 kDa.

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Description

HER3 Protein, a vital tyrosine-protein kinase and neuregulin cell surface receptor, activates upon binding to neuregulin-1 (NRG1), enhancing phosphorylation on tyrosine residues and associating with the p85 subunit of phosphatidylinositol 3-kinase. It is also activated by CSPG5 and plays a crucial role in regulating myeloid cell differentiation. HER3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HER3 Protein, Mouse (HEK293, His) is 622 a.a., with molecular weight of 90-120 kDa.
Background

HER3 protein is a crucial tyrosine-protein kinase functioning as a cell surface receptor for neuregulins. Upon binding neuregulin-1 (NRG1), it undergoes activation, leading to increased phosphorylation on tyrosine residues and subsequent association with the p85 subunit of phosphatidylinositol 3-kinase. Additionally, HER3 protein can be activated by CSPG5. Notably, it plays a significant role in regulating myeloid cell differentiation.
Species

Mouse
Source

HEK293
Tag

C-6*His
Accession

Q61526 (S20-H641)
Gene ID
Molecular Construction
N-term
HER3 (S20-H641)
Accession # Q61526
6*His
C-term
Synonyms
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3
AA Sequence

SEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPH

Molecular Weight

90-120 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

HER3 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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