2. Gene
  3. Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Her3; Erbb-3; Erbb3r

Gene ID: 13867 | Gene type: protein coding

About Erbb3

Chromosome 10: 128,403,392-128,425,521 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 280 orthologues, 53 paralogues and is associated with 81 phenotypes. Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products(1)

mRNA Protein Name
NM_010153.2 NP_034283.1 receptor tyrosine-protein kinase erbB-3 precursor

Erbb3 Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (55 - 166)

Furin-like

Furin-like: pfam00757 (178 - 328)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 473)

GF_recep_IV

GF_recep_IV: pfam14843 (498 - 629)

TM_ErbB3

TM_ErbB3: cd12095 (637 - 673)

PKc_like

PKc_like: cl21453 (698 - 976)

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  • 1339 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-3

avian erythroblastosis oncogene B 3 receptor

c-erbB-3

glial growth factor receptor

proto-oncogene-like protein c-ErbB-3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Recombinant Erbb3 Proteins

Cat. No. Product Name Accession Purity
HY-P70857 HER3 Protein, Mouse (HEK293, His) Q61526 (S20-H641) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99275 Patritumab Inhibitor 98.94% Phase 3
HY-P99268 Seribantumab ≥95.0% Phase 2
HY-P99866 Duligotuzumab 97.93% Phase 2
HY-P99672 Istiratumab Inhibitor / Phase 2
HY-P99304 Lumretuzumab Inhibitor 95.00% Phase 1
HY-P99461 Barecetamab Inhibitor 97.96% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13050 Sapitinib Inhibitor 99.93% Unkown
HY-100848 TX1-85-1 Inhibitor 98.04% Unkown
HY-18609 PD158780 Inhibitor 99.56% Unkown
HY-118998 TX2-121-1 Inhibitor / Unkown
HY-RS04469 ERBB3 Human Pre-designed siRNA Set A / Unkown
HY-RS04470 Erbb3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04471 Erbb3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erbb3 NCBI NCBI:2065
Rattus norvegicus Erbb3 NCBI NCBI:29496
Macaca mulatta Erbb3 NCBI NCBI:711407