1198097-97-0
Chemical Structure
Mirin
- CAS No.: 1198097-97-0
- Formula:C10H8N2O2S
- Molecular Weight:220.25
IUPAC Name: (Z)-2-amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one
InChIKey: YBHQCJILTOVLHD-YVMONPNESA-N
SMILES: O=C1N=C(S/C1=C\C2=CC=C(C=C2)O)N
Biological Activity: Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1][2].
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Mirin | 99.63% | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells. | ||||||||||||||||||||
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References
- [1]. Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107. [Content Brief]
- [2]. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51. [Content Brief]
