2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. (E/Z)-Mirin

(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity.

For research use only. We do not sell to patients.

CAS No. : 299953-00-7

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10 mM * 1 mL in DMSO
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of (E/Z)-Mirin:

(E/Z)-Mirin Related Antibodies

Top Publications Citing Use of Products

    (E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14.

    ΔATAC profile of editing loci Emx1 (left) and Tyr (right) under different concentrations of (E/Z)-Mirin (25-200 μM) in NIH3T3 cells.

    (E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2026 Mar 5;33(3):470-486.e14.

    (E/Z)-Mirin (50 μM; 2 d) reduced the genome-editing-induced stem cell loss without compromising editing efficiency.

    (E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Jun;27(6):992-1005.

    (E/Z)-Mirin (100 μM; 1 h) decreased RNA:DNA hybrids at DSBs.

    (E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2025 Jan 3;21(1):e1012824.  [Abstract]

    (E/Z)-Mirin (25-50 μM; 5 d) decreased the levels of HBeAg in HepG2-NTCP-K7 cells in a dose-dependent manner.

    (E/Z)-Mirin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 18:e2307751.  [Abstract]

    MRE11 inhibitor (E/Z)-Mirin (50 µM; 4 h) alleviated HU-induced genomic instability in prelamin A-expressing cells.

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    Description

    (E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].

    In Vitro

    Mirin inhibits H2AX phosphorylation with an IC50 of 66 μM. Mirin also inhibits ATM-dependent phosphorylation of downstream targets Nbs1 and Chk2, as well as MRN-dependent autophosphorylation of ATM at Ser1981 in DSB reactions. Mirin at concentrations of 50 μM and 100 μM induces significant G2 arrest. Mirin (10-100 μM) inhibits homology-dependent DNA repair in TOSA4 cells[1].
    BRCA2-deficient cells also show hypersensitivity to the Mre11 inhibitor Mirin[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    (E/Z)-Mirin Related Antibodies
    Molecular Weight

    220.25

    Formula

    C10H8N2O2S
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 83.33 mg/mL (378.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.5403 mL 22.7015 mL 45.4030 mL
    5 mM 0.9081 mL 4.5403 mL 9.0806 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.5403 mL 22.7015 mL 45.4030 mL 113.5074 mL
    5 mM 0.9081 mL 4.5403 mL 9.0806 mL 22.7015 mL
    10 mM 0.4540 mL 2.2701 mL 4.5403 mL 11.3507 mL
    15 mM 0.3027 mL 1.5134 mL 3.0269 mL 7.5672 mL
    20 mM 0.2270 mL 1.1351 mL 2.2701 mL 5.6754 mL
    25 mM 0.1816 mL 0.9081 mL 1.8161 mL 4.5403 mL
    30 mM 0.1513 mL 0.7567 mL 1.5134 mL 3.7836 mL
    40 mM 0.1135 mL 0.5675 mL 1.1351 mL 2.8377 mL
    50 mM 0.0908 mL 0.4540 mL 0.9081 mL 2.2701 mL
    60 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.8918 mL
    80 mM 0.0568 mL 0.2838 mL 0.5675 mL 1.4188 mL
    100 mM 0.0454 mL 0.2270 mL 0.4540 mL 1.1351 mL
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    (E/Z)-Mirin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    (E/Z)-Mirin299953-00-7ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedH2AXphosphorylationChk2G2arrestDSBrepairInhibitorinhibitorinhibit

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