299953-00-7
299953-00-7
Chemical Structure
(E/Z)-Mirin
- CAS No.: 299953-00-7
- Formula:C10H8N2O2S
- Molecular Weight:220.25
IUPAC Name: (E)-2-amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one
InChIKey: YBHQCJILTOVLHD-VMPITWQZSA-N
SMILES: O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2
Biological Activity: (E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E/Z)-Mirin | 99.22% | (E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity. | ||||||||||||||||||||
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References
- [1]. Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4(2):119-125. [Content Brief]
- [2]. Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72(11):2814-2821. [Content Brief]
