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PFM39 

Cat. No.: HY-120951 Purity: 98.02%
Handling Instructions

PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity.

For research use only. We do not sell to patients.

PFM39 Chemical Structure

PFM39 Chemical Structure

CAS No. : 1310744-67-2

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Estimated Time of Arrival: December 31
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100 mg USD 1180 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity[1].

In Vitro

PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1].
PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

219.26

Formula

C₁₀H₉N₃OS

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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PFM39
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