1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

AZD0156 (Synonyms: AZD-0156; AZD 0156)

Cat. No.: HY-100016 Purity: 98.00%
Data Sheet SDS Handling Instructions

AZD0156 is an orally active, potent and selective ATM kinase inhibitor, used for cancer treatment.

For research use only. We do not sell to patients.
AZD0156 Chemical Structure

AZD0156 Chemical Structure

CAS No. : 1821428-35-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
5 mg $90 In-stock
10 mg $140 In-stock
50 mg $400 In-stock
100 mg $650 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

AZD0156 is an orally active, potent and selective ATM kinase inhibitor, used for cancer treatment.

In Vitro

AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02588105 AstraZeneca|INC Research Advanced Solid Tumours November 10, 2015 Phase 1
NCT02588105 AstraZeneca|INC Research Advanced Solid Tumours November 10, 2015 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1666 mL 10.8328 mL 21.6657 mL
5 mM 0.4333 mL 2.1666 mL 4.3331 mL
10 mM 0.2167 mL 1.0833 mL 2.1666 mL
Cell Assay
[1]

AZD0156 is dissolved in 100% DMSO.

HT29 cells are seeded into 384 well assay plates at a density of 6000 cells/well in 40 μL EMEM medium containing 1% L glutamine and 10% FBS and allowed to adhere overnight. The following morning compound of Formula (I) in 100% DMSO is added to assay plates by acoustic dispensing. After lh incubation at 37°C and 5% C02, 40 nL of 3 mM 4NQO in 100% DMSO is added to all wells by acoustic dispensing, except minimum control wells which are left untreated with 4NQO to generate a null response control. Plates are returned to the incubator for a further lh. Then cells are fixed by adding 20 μL of 3.7% formaldehyde in PBS solution and incubating for 20 mins at r.t.. Then 20 μL of 0.1% Triton XI 00 in PBS is added and incubated for 10 minutes at r.t., to permeabalise cells. Then the plates are washed once with 50 μL/well PBS, using a Biotek EL405 plate washer. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
M.Wt

461.56

Formula

C₂₆H₃₁N₅O₃

CAS No.

1821428-35-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6.2 mg/mL (Need ultrasonic and warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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AZD0156
Cat. No.:
HY-100016
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