1. Anti-infection
    Metabolic Enzyme/Protease
  2. Parasite
    Cytochrome P450
    Antibiotic
  3. Atovaquone

Atovaquone (Synonyms: Atavaquone)

Cat. No.: HY-13832 Purity: 99.81%
Handling Instructions

Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia.

For research use only. We do not sell to patients.

Atovaquone Chemical Structure

Atovaquone Chemical Structure

CAS No. : 95233-18-4

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and  P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

IC50 & Target

IC50: 460 nM (human cytochrome bc1); 2.0 nM (P. falciparum cytochrome bc1)[1]

In Vitro

Atovaquone targets to the Qo site of the Plasmodium cytochrome bc1 complex of the mitochondrial electron transport chain[1].
Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC50 of 67 nM providing further evidence of the transmission blocking potential of this molecule[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICSBP−/− mice infected with 10 cysts of the ME49 strain of T. gondii[2]
Dosage: 100 mg/kg
Administration: Oral administration
Result: Improved mice survival rate to 22 days compared to vehicle.
Clinical Trial
Molecular Weight

366.84

Formula

C₂₂H₁₉ClO₃

CAS No.

95233-18-4

SMILES

O=C1C([[email protected]]2CC[[email protected]](C3=CC=C(Cl)C=C3)CC2)=C(O)C(C4=C1C=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (22.71 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7260 mL 13.6299 mL 27.2598 mL
5 mM 0.5452 mL 2.7260 mL 5.4520 mL
10 mM 0.2726 mL 1.3630 mL 2.7260 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.83 mg/mL (2.26 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AtovaquoneAtavaquoneParasiteCytochrome P450AntibioticCYPsPlasmodiumneumocystispneumoniatoxoplasmosismalariababesiaInhibitorinhibitorinhibit

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Atovaquone
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