Trimethyl chitosan
Based on 1 Customer Validation
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles.
For research use only. We do not sell to patients.
- CAS No.: 52349-26-5
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Trimethyl chitosan (0.05-1.0% (w/v); 2-4 h) reduced transepithelial electrical resistance (TEER) in a concentration-dependent manner in Caco-2 cell monolayer experiments and significantly increased the transmembrane transport efficiency of 14C-mannitol without significantly affecting cell viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 52349-26-5
-
Appearance Solid
-
Color Off-white to light yellow
-
SMILES
OC[C@@H]1[C@@H](C)[C@H](O)[C@@H]([N+](C)(C)C)[C@H](OC)O1.[Cl-].[n]
-
Synonyms
N,N,N-Trimethylchitosan
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 33.33 mg/mL (ultrasonic and warming and heat to 60°C)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Thanou MM, et al. Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers. J Control Release. 2000 Feb 14;64(1-3):15-25. [Content Brief]
[2]. Mourya VK, et al. Trimethyl chitosan and its applications in drug delivery. J Mater Sci Mater Med. 2009 May;20(5):1057-79. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz