Iso cephalomannine 

Iso cephalomannine is a tubulin-targeting cytotoxic agent. Iso cephalomannine induces cytotoxicity in breast cancer cells. Iso cephalomannine can be used in breast cancer-related research^[1].

Iso cephalomannine (compound 1d) exhibits reduced tubulin-binding activity in cell-free microtubule assembly assays, with an ED₅₀ ratio of 1.1 relative to Paclitaxel (HY-B0015)^[1].
Iso cephalomannine exhibits low cytotoxicity against human breast cancer MCF7 cells, with an ED₅₀ ratio of 12 relative to Paclitaxel (HY-B0015)^[1].
Iso cephalomannine shows no detectable cytotoxicity against MCF7-R drug-resistant human breast cancer cells, with an ED₅₀ greater than 5000 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

831.90

C₄₅H₅₃NO₁₄

173101-54-7

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gabetta B, et al. Paclitaxel analogues from Taxus x media cv. Hicksii. J Nat Prod. 1999;62(2):219-223.  [Content Brief]