2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Sirtuin Endogenous Metabolite
  4. Nicotinamide riboside

Nicotinamide riboside, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Nicotinamide riboside chloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Nicotinamide riboside Chemical Structure

Nicotinamide riboside Chemical Structure

CAS No. : 1341-23-7

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Other In-stock Forms of Nicotinamide riboside:

Other Forms of Nicotinamide riboside:

Nicotinamide riboside Related Antibodies

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Description

Nicotinamide riboside, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

Human Endogenous Metabolite

 

In Vitro

Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide riboside Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 nM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo

Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: p.o.; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
Clinical Trial
Molecular Weight

255.25

Formula

C11H15N2O5
CAS No.
SMILES

NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O
Structure Classification
Initial Source

milk
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nicotinamide riboside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicotinamide riboside1341-23-7SirtuinEndogenous MetaboliteNAD+oxidativemetabolismmetabolicabnormalitiesdietarysupplementsorallyvitaminB3niacinAlzheimer’sCOVID-19PARPInhibitorinhibitorinhibit

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