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Nicotinamide riboside triflate

28 Cited Publications
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Based on 28 publication(s) in Google Scholar

Nicotinamide riboside triflate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside triflate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside triflate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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  • CAS No.: 445489-49-6
  • Formula: C12H15F3N2O8S
  • Molecular Weight:404.32
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Nicotinamide riboside triflate Chemical Structure
    Nicotinamide riboside triflate Chemical Structure
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
  • Experimental Validation Results for Nicotinamide riboside triflate
CAS No.: 445489-49-6
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Bio/Physico-chemical AssayHistological Imaging/StainingCell Imaging/StainingIn Vivo Efficacy StudyIHC2D/3D Cell Culture and DifferentiationCell Proliferation/Viability AssayIFWB
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  • In Vivo Efficacy Study
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All Endogenous Metabolite Isoforms

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  • Nicotinamide riboside triflate Chemical Structure
    Nicotinamide riboside triflate Chemical Structure
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    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     Effect of SIRT3 agonist (Nicotinamide riboside chloride; 0-1600 μM) on the proliferation of MC3T3-E1 cells was determined by CCK-8 assay after 2 days of stimulation

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     IF staining of SIRT3, BNIP3, NIX and DRP1 expression in MC3T3-E1 cells treated with DEX and SIRT3 agonist (800 μm).

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 26;13(1):18. [Abstract]

    Customer Validation
     WB analysis of SIRT3, BNIP3, NIX, DRP1, MFN1 and MFN2 expression in MC3T3-E1 cells treated with DEX and SIRT3 agonist (800 μM).

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.

    Customer Validation
     Representative hematoxylin and eosin (H&E)-stained sections of small intestines were collected at the end of the experiment (NR:Nicotinamide riboside,400 mg/kg/day； po for 4 weeks) or vehicle (phosphate buffer; at the same dose and volume as NR) once a day after irradiation exposure in C57BL/6 mouse)

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.

    Customer Validation
     Immunofluorescence detection of Ki-67 and ZO-1 in IECs between groups with NR (Nicotinamide riboside; 0.5 mM; 24 h).

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Mar 31.

    Customer Validation
     Morphology of the SI and colon (NR:Nicotinamide riboside,400 mg/kg/day； po for 4 weeks) or vehicle (phosphate buffer; at the same dose and volume as NR) once a day after irradiation exposure in C57BL/6 mouse)

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1. [Abstract]

    Customer Validation
     The effect of different concentrations of NR (Nicotinamide riboside chloride;200,400, 800, 1000 μM) on primary human trabecular meshwork cells' viability after 24 and 72 hours of treatment, was determined by using the CCK-8 assay

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Oct:491:117066. [Abstract]

    Customer Validation
     WB images of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions in DRG tissues. Quantification of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions normalized with β-actin expressions and the Saline+Saline treated samples was set to 1 (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR (400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Oct:491:117066. [Abstract]

    Customer Validation
     The representative images depicting the expression of AcK68-MnSOD in each group were utilized for immunohistochemical detection (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR(400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Cells. 2023 Oct 2;12(19):2396. [Abstract]

    Customer Validation
     THP-1 cells were supplemented with 200 µM NR (Nicotinamide riboside chloride) for 4 h before treatment with CEES or HN2 in growth medium (“Ctrl”) for 30 min. The “0” refers to solvent control. After exposure, cells were incubated with fresh growth medium with or without 200 µM NR for 20 h, and cell viability was measured with alamarBlue assay

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Mar 2;6(1):235. [Abstract]

    Customer Validation
     The cells were pretreated with NR (0.5 µM) for 1 h followed by post-incubation with LPS (1 µg/mL) or H2O2 (100 µM) for 24 h, quantitative analysis of cell viability in each group after LPS stimulation and H2O2 stimulation.

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    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]

    Customer Validation
     MitoParaquat (0.1 μM, 30 min) abolished the inhibition of platelet aggregation by nicotinamide riboside (1 mM, 30 min) or olaparib (20 μM, 30 min) in resting platelets from LST patients.

  • 1/16

    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Nov:57:102507. [Abstract]

    Customer Validation
     MitoParaquat (0.1 μM, 30 min) did not interrupt the improvements in mitochondrial respiration induced by nicotinamide riboside (1 mM) or olaparib (20 μM) in resting platelets from LST patients.

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    Nicotinamide riboside triflate purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Nov 10;11(1):192.

    Customer Validation
     Relative ATP, NAD+, NADH, and NAD+/NADH levels in NR (Nicotinamide ribosid, 100 mM, 24 h) treatment SY5Y cells.

  • Nicotinamide riboside triflate