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SRT 1720 dihydrochloride

63 Cited Publications
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Based on 63 publication(s) in Google Scholar

SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

For research use only. We do not sell to patients.

  • Purity: 99.60%
  • CAS No.: 2468639-77-0
  • Formula: C25H25Cl2N7OS
  • Molecular Weight:542.48
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • SRT 1720 dihydrochloride Chemical Structure
    SRT 1720 dihydrochloride Chemical Structure
  • Experimental Validation Results for SRT 1720 dihydrochloride
  • Experimental Validation Results for SRT 1720 dihydrochloride
  • Experimental Validation Results for SRT 1720 dihydrochloride
  • Experimental Validation Results for SRT 1720 dihydrochloride
  • Experimental Validation Results for SRT 1720 dihydrochloride
  • Experimental Validation Results for SRT 1720 dihydrochloride
CAS No.: 2468639-77-0
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • SRT 1720 dihydrochloride Chemical Structure
    SRT 1720 dihydrochloride Chemical Structure
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    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2023 Jun:231:109464. [Abstract]

    Customer Validation
     SRT1720 (1 μM; 1 h) reverses UVA (Using ultraviolet A)-inhibited expression of PGC-1α, NRF2 and TFAM in B4G12 cells.

  • 1/16

    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2023 Jun:231:109464. [Abstract]

    Customer Validation
     SRT1720 (1 μM; 1 h) effectively decreases the levels of cell death and ROS accumulation in the UVA (Using ultraviolet A)-irradiated B4G12 cells.

  • 1/16

    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]

    Customer Validation
     Huh7 cells were incubated with GFP-SARS-CoV-2 at an MOI of 0.01 for 1 h and then treated with the SIRT1 agonist SRT1720 at the indicated doses for 48 h. Microscopy imaging was performed to analyze SARS-CoV-2 replication. Blue: DAPI (nuclear staining).

  • 1/16

    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]

    Customer Validation
     The dose response curves of SRT1720 against SARS-CoV-2. Huh7 cells were infected with GFP-SARS-CoV-2 for 1 h and then treated with the SIRT1 agonist SRT1720 at the indicated doses for 24 h. Cells were harvested for total RNA extraction. Viral NP expression was quantified by real-time PCR and then normalized to the expression of the 36B4 gene. Asterisks represent statistical significance based on two-tailed unpaired Student’s t test (*P  <  0.05, **P  <  0.01)

  • 1/16

    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Hypertension. 2016 Nov;68(5):1191-1199. [Abstract]

    Customer Validation
     SRT1720 rescues the downregulation of SIRT1 activity and protein expression in the aortas of KL+/– mice. A, Representative Western blot bands of Acetyl-P53 and total P53 and the quantification of SIRT1 activity. Data are expressed as the ratio of acetyl-p53/total P53. B, Representative Western blot bands and quantitative analysis of SIRT1 protein expression in aortas. Protein expression is normalized to β-actin, and the relative expression calculated as the fold change relative

  • 1/16

    SRT 1720 dihydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2016 Dec 15:264:1-11. [Abstract]

    Customer Validation
     The HNF1α, FXR, Mrp2 and Bsep protein levels are decreased after EE administration and significantly increased by SRT1720 in a dose dependent manner, which is in accordance with the mRNA levels.

  • SRT 1720 dihydrochloride