SIRT5 inhibitor 1
Based on 5 publication(s) in Google Scholar
SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
For research use only. We do not sell to patients.
- Purity: 98.67%
- CAS No.: 2166487-21-2
- Formula: C31H39FN6O6S2
- Molecular Weight:674.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SIRT5 inhibitor 1
More
Biological Activity
IC50: 0.11 μM (Sirtuin)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
29 μM
Compound: 3d
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Cytotoxicity against human MOLM-13 cells
Cytotoxicity against human MOLM-13 cells
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[PMID: 35802779] |
| OCI-AML2 | IC50 |
>20 μM
Compound: 3d
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Cytotoxicity against human OCI-AML2 cells
Cytotoxicity against human OCI-AML2 cells
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[PMID: 35802779] |
| SKM-1 | IC50 |
10 μM
Compound: 3d
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Cytotoxicity against human SKM-1 cells
Cytotoxicity against human SKM-1 cells
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[PMID: 35802779] |
SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2166487-21-2
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Appearance Solid
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Molecular Weight 674.81
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Formula C31H39FN6O6S2
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Color White to off-white
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SMILES
O=S(N[C@@H](CCCCNC(NCCC(O)=O)=S)C(N[C@H](C(NC1CCC1)=O)CC2=CNC3=CC=CC=C23)=O)(C4=CC(F)=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
2022 Oct 17;13(1):6121. PMID: 36253417 -
EMBO J
SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. [Abstract]2024 Jun;43(12):2337-2367. PMID: 38649537 -
J Cell Mol Med
Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1. [Abstract]2020 Dec;24(23):14039-14049. PMID: 33103371 -
bioRxiv
2022 Jan 5:2022.01.04.474979. PMID: 35018374 -
Solvent & Solubility
DMSO : 50 mg/mL (74.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.85 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (1.85 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4819 mL | 7.4095 mL | 14.8190 mL | 37.0475 mL |
| 5 mM | 0.2964 mL | 1.4819 mL | 2.9638 mL | 7.4095 mL | |
| 10 mM | 0.1482 mL | 0.7409 mL | 1.4819 mL | 3.7047 mL | |
| 15 mM | 0.0988 mL | 0.4940 mL | 0.9879 mL | 2.4698 mL | |
| 20 mM | 0.0741 mL | 0.3705 mL | 0.7409 mL | 1.8524 mL | |
| 25 mM | 0.0593 mL | 0.2964 mL | 0.5928 mL | 1.4819 mL | |
| 30 mM | 0.0494 mL | 0.2470 mL | 0.4940 mL | 1.2349 mL | |
| 40 mM | 0.0370 mL | 0.1852 mL | 0.3705 mL | 0.9262 mL | |
| 50 mM | 0.0296 mL | 0.1482 mL | 0.2964 mL | 0.7409 mL | |
| 60 mM | 0.0247 mL | 0.1235 mL | 0.2470 mL | 0.6175 mL |
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