Sirtuin-1 inhibitor 1
Based on 1 Customer Validation
Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 945114-10-3
- Formula: C20H17N3O2
- Molecular Weight:331.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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SIRT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
23.94 μM
Compound: 14l
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Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 32663641] |
| HT-29 | IC50 |
12.743 μM
Compound: 14l
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 32663641] |
Chemical Information
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CAS No. 945114-10-3
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Appearance Solid
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Molecular Weight 331.37
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Formula C20H17N3O2
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Color White to off-white
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SMILES
O=C(NC1=CC=C(NC(C2=CC=CC=C2)=O)C=C1)NC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20.83 mg/mL (62.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0178 mL | 15.0889 mL | 30.1777 mL | 75.4444 mL |
| 5 mM | 0.6036 mL | 3.0178 mL | 6.0355 mL | 15.0889 mL | |
| 10 mM | 0.3018 mL | 1.5089 mL | 3.0178 mL | 7.5444 mL | |
| 15 mM | 0.2012 mL | 1.0059 mL | 2.0118 mL | 5.0296 mL | |
| 20 mM | 0.1509 mL | 0.7544 mL | 1.5089 mL | 3.7722 mL | |
| 25 mM | 0.1207 mL | 0.6036 mL | 1.2071 mL | 3.0178 mL | |
| 30 mM | 0.1006 mL | 0.5030 mL | 1.0059 mL | 2.5148 mL | |
| 40 mM | 0.0754 mL | 0.3772 mL | 0.7544 mL | 1.8861 mL | |
| 50 mM | 0.0604 mL | 0.3018 mL | 0.6036 mL | 1.5089 mL | |
| 60 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2574 mL |
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