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SRT 1720 monohydrochloride

65 Cited Publications
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Based on 65 publication(s) in Google Scholar

SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

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  • Reinheit : 99.37%
  • CAS. Nr.: 2060259-60-9
  • Formel: C25H24ClN7OS
  • Molecular Weight:506.02
  • Speicherung:

    4°C, stored under nitrogen, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

  • SRT 1720 monohydrochloride Chemical Structure
    SRT 1720 monohydrochloride Chemical Structure
  • Experimental Validation Results for SRT 1720 monohydrochloride
  • Experimental Validation Results for SRT 1720 monohydrochloride
  • Experimental Validation Results for SRT 1720 monohydrochloride
  • Experimental Validation Results for SRT 1720 monohydrochloride
  • Experimental Validation Results for SRT 1720 monohydrochloride
  • Experimental Validation Results for SRT 1720 monohydrochloride
CAS. Nr.: 2060259-60-9
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  • SRT 1720 monohydrochloride Chemical Structure
    SRT 1720 monohydrochloride Chemical Structure
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    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2023 Jun:231:109464. [Abstract]

    Customer Validation
     SRT1720 (1 μM; 1 h) reverses UVA (Using ultraviolet A)-inhibited expression of PGC-1α, NRF2 and TFAM in B4G12 cells.

  • 1/16

    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2023 Jun:231:109464. [Abstract]

    Customer Validation
     SRT1720 (1 μM; 1 h) effectively decreases the levels of cell death and ROS accumulation in the UVA (Using ultraviolet A)-irradiated B4G12 cells.

  • 1/16

    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]

    Customer Validation
     Huh7 cells were incubated with GFP-SARS-CoV-2 at an MOI of 0.01 for 1 h and then treated with the SIRT1 agonist SRT1720 at the indicated doses for 48 h. Microscopy imaging was performed to analyze SARS-CoV-2 replication. Blue: DAPI (nuclear staining).

  • 1/16

    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2022 Aug;19(8):872-882. [Abstract]

    Customer Validation
     The dose response curves of SRT1720 against SARS-CoV-2. Huh7 cells were infected with GFP-SARS-CoV-2 for 1 h and then treated with the SIRT1 agonist SRT1720 at the indicated doses for 24 h. Cells were harvested for total RNA extraction. Viral NP expression was quantified by real-time PCR and then normalized to the expression of the 36B4 gene. Asterisks represent statistical significance based on two-tailed unpaired Student’s t test (*P  <  0.05, **P  <  0.01)

  • 1/16

    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Hypertension. 2016 Nov;68(5):1191-1199. [Abstract]

    Customer Validation
     SRT1720 rescues the downregulation of SIRT1 activity and protein expression in the aortas of KL+/– mice. A, Representative Western blot bands of Acetyl-P53 and total P53 and the quantification of SIRT1 activity. Data are expressed as the ratio of acetyl-p53/total P53. B, Representative Western blot bands and quantitative analysis of SIRT1 protein expression in aortas. Protein expression is normalized to β-actin, and the relative expression calculated as the fold change relative

  • 1/16

    SRT 1720 monohydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2016 Dec 15:264:1-11. [Abstract]

    Customer Validation
     The HNF1α, FXR, Mrp2 and Bsep protein levels are decreased after EE administration and significantly increased by SRT1720 in a dose dependent manner, which is in accordance with the mRNA levels.

  • SRT 1720 monohydrochloride