1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
  2. Sirtuin
    Autophagy
  3. SRT 1720 Hydrochloride

SRT 1720 Hydrochloride 

Cat. No.: HY-15145 Purity: 99.92%
Handling Instructions

SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.

For research use only. We do not sell to patients.

SRT 1720 Hydrochloride Chemical Structure

SRT 1720 Hydrochloride Chemical Structure

CAS No. : 2060259-60-9

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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of SRT 1720 Hydrochloride:

Top Publications Citing Use of Products

    SRT 1720 Hydrochloride purchased from MCE. Usage Cited in: Hypertension. 2016 Nov;68(5):1191-1199.

    SRT1720 rescues the downregulation of SIRT1 activity and protein expression in the aortas of KL+/– mice. A, Representative Western blot bands of Acetyl-P53 and total P53 and the quantification of SIRT1 activity. Data are expressed as the ratio of acetyl-p53/total P53. B, Representative Western blot bands and quantitative analysis of SIRT1 protein expression in aortas. Protein expression is normalized to β-actin, and the relative expression calculated as the fold change relative

    SRT 1720 Hydrochloride purchased from MCE. Usage Cited in: Toxicol Lett. 2016 Dec 15;264:1-11.

    The HNF1α, FXR, Mrp2 and Bsep protein levels are decreased after EE administration and significantly increased by SRT1720 in a dose dependent manner, which is in accordance with the mRNA levels.

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    Description

    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3[1].

    IC50 & Target[1]

    SIRT1

    0.10 μM (EC50)

    SIRT1

    0.16 μM (EC1.5)

    SIRT2

    37 μM (EC1.5)

    In Vitro

    SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300[2].

    In Vivo

    SRT 1720 (10, 30, 100 mg/kg, p.o.) treatment significantly reduces fasting blood glucose to near normal levels in Lepob/ob mice[1].
    SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1[2].
    SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice[3].

    Molecular Weight

    506.02

    Formula

    C₂₅H₂₄ClN₇OS

    CAS No.

    2060259-60-9

    SMILES

    O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C=CC=C3)C4=CN5C(CN6CCNCC6)=CSC5=N4.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (123.51 mM; Need ultrasonic)

    H2O : 15.7 mg/mL (31.03 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9762 mL 9.8810 mL 19.7621 mL
    5 mM 0.3952 mL 1.9762 mL 3.9524 mL
    10 mM 0.1976 mL 0.9881 mL 1.9762 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.75 mg/mL (5.43 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.75 mg/mL (5.43 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [1]

    Mice: Nine week old C57BL/6 male mice are fed a high fat diet (60% calories from fat) until their mean body weight reach approximately 40 g. The mice are then divided into test groups (6-10 per group). SRT1460 (100 mg/kg), SRT 1720 (100 mg/kg), SRT501 (500 mg/kg) and BRL49653 (5 mg/kg) are administered once daily via oral gavage. The vehicle used is 2% HPMC + 0.2% DOSS. Individual mouse body weights are measured twice weekly. At 2, 4, 6, 8 and 10 weeks of dosing a fed blood glucose measure is taken and after 5 weeks of treatment an IPGTT is conducted on all mice from each of the groups. After 10 weeks of treatment, an ITT is conducted. Statistical analysis is completed using the JMP program. Data are analyzed by a one way ANOVA with comparison to control using a Dunnett’s Test. A p value < 0.05 indicates a significant difference between groups.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.92%

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    Keywords:

    SRT 1720SRT1720SRT-1720SirtuinAutophagyInhibitorinhibitorinhibit

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    Product Name:
    SRT 1720 Hydrochloride
    Cat. No.:
    HY-15145
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