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Malic enzyme inhibitor ME1 (Synonyms: ME1)

Cat. No.: HY-124861 Purity: 98.08%
Handling Instructions

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM.

For research use only. We do not sell to patients.

Malic enzyme inhibitor ME1 Chemical Structure

Malic enzyme inhibitor ME1 Chemical Structure

CAS No. : 522649-59-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 197 In-stock
Estimated Time of Arrival: December 31
1 mg USD 85 In-stock
Estimated Time of Arrival: December 31
5 mg USD 255 In-stock
Estimated Time of Arrival: December 31
10 mg USD 440 In-stock
Estimated Time of Arrival: December 31
25 mg USD 880 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].

IC50 & Target

IC50: 0.15 μM (Malic enzyme)[1]

In Vitro

Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers[2].
Malic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell[2].
Malic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells[2].

Cell Viability Assay[2]

Cell Line: HCT116 and HT29 cell line
Concentration: 50 μM
Incubation Time: 72 hours
Result: Showed a significant reduction in total cell numbers.
Molecular Weight

351.40

Formula

C₂₀H₂₁N₃O₃

CAS No.

522649-59-8

SMILES

O=C(C(N1CCN(C2=CC=C(O)C=C2)CC1)C3)N(C4=CC=CC=C4)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (355.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8458 mL 14.2288 mL 28.4576 mL
5 mM 0.5692 mL 2.8458 mL 5.6915 mL
10 mM 0.2846 mL 1.4229 mL 2.8458 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product name:
Malic enzyme inhibitor ME1
Cat. No.:
HY-124861
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