522649-59-8
522649-59-8
Chemical Structure
Malic enzyme inhibitor ME1
Synonym(s): ME1
- CAS No.: 522649-59-8
- Formula:C20H21N3O3
- Molecular Weight:351.40
IUPAC Name: 3-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione
InChIKey: JJFJQFJFFVLMCX-UHFFFAOYSA-N
SMILES: O=C(C(N1CCN(C2=CC=C(O)C=C2)CC1)C3)N(C4=CC=CC=C4)C3=O
Biological Activity: Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].
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Malic enzyme inhibitor ME1 | 99.69% | Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM. | ||||||||||||||||||||
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References
- [1]. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. [Content Brief]
- [2]. Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. [Content Brief]
Keywords
