1. Apoptosis
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  3. VBIT-3

VBIT-3 

Cat. No.: HY-135571
Handling Instructions

VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.

For research use only. We do not sell to patients.

VBIT-3 Chemical Structure

VBIT-3 Chemical Structure

CAS No. : 2088463-66-3

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Description

VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

IC50 & Target

Kd: 31.3 μM (VDAC1)[1]
Apoptosis[1]

In Vitro

VBIT-3 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction[1].
VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively[1].

Apoptosis Analysis[1]

Cell Line: HEK-293 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time:
Result: Inhibited apoptosis with an IC50 of 7.5±0.27μM.
Molecular Weight

453.84

Formula

C₂₁H₁₉ClF₃N₃O₃

CAS No.

2088463-66-3

SMILES

O=C(C(N1CCN(C2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VBIT-3VBIT3VBIT 3ApoptosisVDAC1oligomerizationneurodegenerativecardiovascularInhibitorinhibitorinhibit

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