1533438-83-3
1533438-83-3
Chemical Structure
TVB-3166
- CAS No.: 1533438-83-3
- Formula:C24H24N4O
- Molecular Weight:384.47
IUPAC Name: 4-(1-(5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile
InChIKey: ICDQFUFDAFKCAX-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C2CN(C(C3=CC(C4=NNC(C)=C4C)=C(C)C=C3C)=O)C2)C=C1
Biological Activity: TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth[1].
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TVB-3166 | 99.69% | TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth. | ||||||||||||||||||||
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References
Keywords
