17397-89-6
17397-89-6
Chemical Structure
Cerulenin
- CAS No.: 17397-89-6
- Formula:C12H17NO3
- Molecular Weight:223.27
IUPAC Name: (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide
InChIKey: GVEZIHKRYBHEFX-NQQPLRFYSA-N
SMILES: O=C([C@@H]1O[C@@H]1C(CC/C=C/C/C=C/C)=O)N
Biological Activity: Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cerulenin | 98.90% | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.62
HY-166062trans-5,6-Epoxy-9(Z),12(Z)-octadecadienoic acid -
Similarity Score 0.62
HY-166241cis-5,6-Epoxy-9(Z),12(Z)-octadecadienoic acid -
Similarity Score 0.61
HY-166239cis-15,16-Epoxy-9(Z),12(Z)-octadecadienoic acid -
Similarity Score 0.60
HY-11351914R(15S)-EET -
Similarity Score 0.60
HY-150084(±)14,15-Epoxyeicosatrienoic acid -
Similarity Score 0.60
HY-N1297014S(15R)-EET -
Similarity Score 0.60
HY-165022(±)14(15)-EpEDE -
Similarity Score 0.60
HY-166245cis-9,10-Epoxy-12(Z),15(Z)-octadecadienoic acid -
Similarity Score 0.60
HY-1321845,6-Epoxyeicosatrienoic acid -
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References
- [1]. Bitencourt TA, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229. [Content Brief]
- [2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol. 2012 Nov 21;11:144. [Content Brief]
- [3]. Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One. 2013 Sep 27;8(9):e75980. [Content Brief]
- [4]. Jeong NY, et al. Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Apoptosis. 2013;18(2):226-237. [Content Brief]
