218137-86-1
218137-86-1
Chemical Structure
C75
- CAS No.: 218137-86-1
- Formula:C14H22O4
- Molecular Weight:254.32
IUPAC Name: 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
InChIKey: VCWLZDVWHQVAJU-UHFFFAOYSA-N
SMILES: O=C(C(C1=C)C(CCCCCCCC)OC1=O)O
Biological Activity: C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
C75 | 99.91% | C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
C75 (Standard) | ≥98% | C75 (Standard) is the analytical standard of C75. This product is intended for research and analytical applications. C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 1.00
HY-12364Atrans-C75 -
Similarity Score 1.00
HY-12364B(−)-C75 -
Similarity Score 1.00
HY-12364C(+)-trans-C75 -
Similarity Score 0.74
HY-N10272(±)-Avenaciolide -
Similarity Score 0.73
HY-N8499Sporothriolide -
Similarity Score 0.66
HY-N14012Cedarmycin B -
Similarity Score 0.63
HY-121034Acaterin -
Similarity Score 0.62
HY-1126754-Octyl itaconate -
Similarity Score 0.62
HY-N14011Cedarmycin A -
Explore the MedChemAI to find more analogs
References
- [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [Content Brief]
- [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [Content Brief]
- [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33. [Content Brief]
- [5]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560. [Content Brief]
