292613-04-8
292613-04-8
Chemical Structure
SW016789
- CAS No.: 292613-04-8
- Formula:C20H19N3OS
- Molecular Weight:349.45
InChIKey: FUSMUZNHMXYEGC-UHFFFAOYSA-N
SMILES: N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
Biological Activity: SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SW016789 | 99.85% | SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Roy G, et al. VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells. Cell Rep. 2025 Jun 24;44(6):115834. [Content Brief]
- [2]. Rodrigues-Dos-Santos K et, al. Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function. Endocrinology. 2022 Jul 1;163(7):bqac081. [Content Brief]
Keywords
