1. Apoptosis
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  3. VBIT-4

VBIT-4 

Cat. No.: HY-129122
Handling Instructions

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.

For research use only. We do not sell to patients.

VBIT-4 Chemical Structure

VBIT-4 Chemical Structure

CAS No. : 2086257-77-2

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Description

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

IC50 & Target

Kd: 17 μM (VDAC1)[1]
Apoptosis[1]

In Vitro

VBIT-4 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively[1].

Apoptosis Analysis[1]

Cell Line: HEK-293 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time:
Result: Inhibited apoptosis with an IC50 of 2.9±0.12 μM.
Molecular Weight

457.87

Formula

C₂₁H₂₃ClF₃N₃O₃

CAS No.

2086257-77-2

SMILES

O=C(NC1=CC=C(Cl)C=C1)CC(CO)N2CCN(C3=CC=C(OC(F)(F)F)C=C3)CC2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VBIT-4VBIT4VBIT 4ApoptosisVDAC1oligomerizationneurodegenerativecardiovascularInhibitorinhibitorinhibit

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VBIT-4
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