1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC
  4. VDAC Inhibitor

VDAC Inhibitor

VDAC Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin
    Inhibitor 99.76%
    Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity.
  • HY-D0086
    DIDS sodium salt
    Inhibitor 99.13%
    DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.
  • HY-108937
    NSC 15364
    Inhibitor 99.75%
    NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
  • HY-129122
    VBIT-4
    Inhibitor 99.11%
    VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases.
  • HY-128777
    WEHI-9625
    Inhibitor 99.46%
    WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.