2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. VDAC
  5. VDAC Inhibitor

VDAC Inhibitor

VDAC Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin
    		Inhibitor 99.76%
    Erastin is a ferroptosis inducer. Erastin shows selective cytotoxicity, targeting cells expressing oncogenic mutants of RAS. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity.
  • HY-D0086
    DIDS sodium salt
    		Inhibitor 99.13%
    DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.
  • HY-108937
    NSC 15364
    		Inhibitor 99.75%
    NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
  • HY-128777
    WEHI-9625
    		Inhibitor 99.05%
    WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.