1. Apoptosis
  2. Apoptosis
    Bcl-2 Family
  3. WEHI-9625

WEHI-9625 

Cat. No.: HY-128777
Handling Instructions

WEHI-9625 is a tricyclic sulfone small molecule inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK, but is completely inactive against both human BAK and the closely related apoptosis effector BAX.

For research use only. We do not sell to patients.

WEHI-9625 Chemical Structure

WEHI-9625 Chemical Structure

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Description

WEHI-9625 is a tricyclic sulfone small molecule inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK, but is completely inactive against both human BAK and the closely related apoptosis effector BAX[1].

IC50 & Target[1]

Bak

 

Bax

 

In Vitro

WEHI-9625 (0-10 µM; Mcl1−/−Bax−/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax−/−, but not Bak−/−, cells[1].

Cell Viability Assay[1]

Cell Line: Mcl1−/−Bax−/− MEFs cells with ABT-737-pretreated
Concentration: 0-10 µM
Incubation Time:
Result: Could prevent cell death.
Molecular Weight

593.71

Formula

C₃₄H₂₇NO₅S₂

SMILES

O=C(C(S1)=CC(CS2(=O)=O)=C1C3=C2C=C(C4=CC=CC=C4C(C5=CC=C(OC)C=C5)=O)C=C3)NCC6=CC=C(C)C=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

WEHI-9625WEHI9625WEHI 9625ApoptosisBcl-2 FamilyInhibitorinhibitorinhibit

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Product name:
WEHI-9625
Cat. No.:
HY-128777
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