1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Elastase
  4. Elastase Inhibitor

Elastase Inhibitor

Elastase Inhibitors (40):

Cat. No. Product Name Effect Purity
  • HY-17443
    Sivelestat
    Inhibitor 98.61%
    Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
  • HY-15651
    Alvelestat
    Inhibitor 99.41%
    Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM.
  • HY-75957
    DMP 777
    Inhibitor 99.75%
    DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
  • HY-17443B
    Sivelestat sodium tetrahydrate
    Inhibitor 99.90%
    Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
  • HY-P5459
    Elafin(human)
    Inhibitor
    Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus.
  • HY-P5995
    MeOSuc-AAPA-CMK
    Inhibitor
    MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase.
  • HY-15891
    GW311616
    Inhibitor 99.30%
    GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM.
  • HY-15891A
    GW311616 hydrochloride
    Inhibitor 98.84%
    GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM.
  • HY-111457A
    BAY-678
    Inhibitor 99.59%
    BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
  • HY-17443A
    Sivelestat sodium
    Inhibitor 99.13%
    Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
  • HY-N6876
    Secologanoside
    Inhibitor ≥99.0%
    Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.
  • HY-P3293A
    Lonodelestat TFA
    Inhibitor 99.86%
    Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF).
  • HY-15652A
    Freselestat quarterhydrate
    Inhibitor ≥99.0%
    Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a Ki of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity.
  • HY-P3293
    Lonodelestat
    Inhibitor
    Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF).
  • HY-19406
    AE-3763
    Inhibitor ≥98.0%
    AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
  • HY-N2395
    Chrysophanol 8-O-glucoside
    Inhibitor 99.26%
    Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity.
  • HY-19254
    ZD-0892
    Inhibitor
    ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
  • HY-103445
    SSR69071
    Inhibitor ≥98.0%
    SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury. SSR69071 displays a higher affinity for human elastase (Ki=0.0168 nM) than for rat (Ki=3 nM), mouse (Ki=1.8 nM), and rabbit (Ki= 58 nM) elastases.
  • HY-100240
    Lodelaben
    Inhibitor
    Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
  • HY-N8164
    19α-Hydroxyasiatic acid
    Inhibitor 99.56%
    19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity.