1. Metabolic Enzyme/Protease
  2. Elastase

GW311616 

Cat. No.: HY-15891 Purity: 99.30%
Handling Instructions

GW311616 is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM; free base form of GW311616A.

For research use only. We do not sell to patients.

GW311616 Chemical Structure

GW311616 Chemical Structure

CAS No. : 198062-54-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of GW311616:

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Description

GW311616 is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM; free base form of GW311616A. IC50 value: 22 nM [1] Target: neutrophil elastase The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin, >3 mM for chymotrypsin and tissue plasminogen activator). Acetylcholinesterase is not inhibited by GW311616A at 100 uM.GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog (Table 4) and hamster despite moderate to high plasma clearance, which indicates that clearance is predominantly extrahepatic.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 44 mg/mL (110.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5155 mL 12.5777 mL 25.1553 mL
5 mM 0.5031 mL 2.5155 mL 5.0311 mL
10 mM 0.2516 mL 1.2578 mL 2.5155 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

397.53

Formula

C₁₉H₃₁N₃O₄S

CAS No.

198062-54-3

SMILES

O=C1[[email protected]@H](C(C)C)[[email protected]@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[[email protected]]3([H])N1S(=O)(C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GW311616
Cat. No.:
HY-15891
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GW311616

Cat. No.: HY-15891