MeOSuc-AAPV-CMK
Based on 1 Customer Validation
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor that simultaneously inhibits Cathepsin G and Proteinase 3. MeOSuc-AAPV-CMK blocks the shedding of FcgRIIIb on the surface of human neutrophils. MeOSuc-AAPV-CMK reverses the elastase-mediated reduction in proinflammatory cytokine production by immune cells, partially restores IL-1β levels in immune cell co-culture systems, and prevents elastase-mediated adiponectin cleavage.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 65144-34-5
- Formula: C22H35ClN4O7
- Molecular Weight:502.99
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Angiogenesis-Related Compound Library
HY-L088
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Peptide Library
HY-L105
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Protease Inhibitor Library
HY-L147
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
All Cathepsin Isoforms
More
Biological Activity
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IL-1β |
MeOSuc-AAPV-CMK (200 μM; 10 min) inhibits Cytochalasin B (HY-16928) + N-Formyl-Met-Leu-Phe (HY-P0224)-induced FcγRIIIb shedding in human neutrophils with an inhibition rate of 70%, but exerts no effect on PMA-induced shedding[1].
MeOSuc-AAPV-CMK (10 μM; 24 h) can partially restore the production levels of IL-1β and TNF-α in human peripheral blood mononuclear cells (PBMCs) treated with neutrophil elastase (NE) and stimulated with heat-inactivated Candida albicans[2].
MeOSuc-AAPV-CMK (10 μM; 24 h) partially restores IL-1β production in human PBMCs stimulated with heat-inactivated Candida albicans and co-cultured with PMNs, but does not alter TNF-α levels[2].
MeOSuc-AAPV-CMK inhibits leukocyte elastase-mediated cleavage of purified mouse full-length adiponectin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human PBMCs
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Concentration:10 μM
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Incubation Time:24 h
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Result:Partially restored the production levels of IL-1β and TNF-α in human peripheral blood mononuclear cells (PBMCs) treated with neutrophil elastase (NE) and stimulated with heat-inactivated Candida albicans.
Partially restored IL-1β production in human PBMCs stimulated with heat-inactivated Candida albicans and co-cultured with PMNs, but does not alter TNF-α levels.
Chemical Information
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CAS No. 65144-34-5
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Appearance Solid
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Molecular Weight 502.99
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Formula C22H35ClN4O7
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Color White to off-white
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Synonyms
Elastase Inhibitor III
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Sequence
{MeOSuc}-Ala-Ala-Pro-Val-{CMK}
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Sequence Shortening
{MeOSuc}-AAPV-{CMK}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (248.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9881 mL | 9.9406 mL | 19.8811 mL | 49.7028 mL |
| 5 mM | 0.3976 mL | 1.9881 mL | 3.9762 mL | 9.9406 mL | |
| 10 mM | 0.1988 mL | 0.9941 mL | 1.9881 mL | 4.9703 mL | |
| 15 mM | 0.1325 mL | 0.6627 mL | 1.3254 mL | 3.3135 mL | |
| 20 mM | 0.0994 mL | 0.4970 mL | 0.9941 mL | 2.4851 mL | |
| 25 mM | 0.0795 mL | 0.3976 mL | 0.7952 mL | 1.9881 mL | |
| 30 mM | 0.0663 mL | 0.3314 mL | 0.6627 mL | 1.6568 mL | |
| 40 mM | 0.0497 mL | 0.2485 mL | 0.4970 mL | 1.2426 mL | |
| 50 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9941 mL | |
| 60 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8284 mL | |
| 80 mM | 0.0249 mL | 0.1243 mL | 0.2485 mL | 0.6213 mL | |
| 100 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4970 mL |
MeOSuc-AAPV-CMK Related Classifications
HY-136888 Related Classifications
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