65144-34-5
Chemical Structure
MeOSuc-AAPV-CMK
Synonym(s): Elastase Inhibitor III
- CAS No.: 65144-34-5
- Formula:C22H35ClN4O7
- Molecular Weight:502.99
IUPAC Name: methyl 4-(((S)-1-(((S)-1-((S)-2-(((S)-1-chloro-4-methyl-2-oxopentan-3-yl)carbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-4-oxobutanoate
InChIKey: PJGDFLJMBAYGGC-XLPNERPQSA-N
SMILES: O=C(N[C@@H](C(C)C)C(CCl)=O)[C@H]1N(C([C@H](C)NC([C@H](C)NC(CCC(OC)=O)=O)=O)=O)CCC1
Biological Activity: MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor that simultaneously inhibits Cathepsin G and Proteinase 3. MeOSuc-AAPV-CMK blocks the shedding of FcgRIIIb on the surface of human neutrophils. MeOSuc-AAPV-CMK reverses the elastase-mediated reduction in proinflammatory cytokine production by immune cells, partially restores IL-1β levels in immune cell co-culture systems, and prevents elastase-mediated adiponectin cleavage[1][2][3].
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MeOSuc-AAPV-CMK | 98.01% | MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor that simultaneously inhibits Cathepsin G and Proteinase 3. MeOSuc-AAPV-CMK blocks the shedding of FcgRIIIb on the surface of human neutrophils. MeOSuc-AAPV-CMK reverses the elastase-mediated reduction in proinflammatory cytokine production by immune cells, partially restores IL-1β levels in immune cell co-culture systems, and prevents elastase-mediated adiponectin cleavage. | ||||||||||||||||||||
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- [1]. Middelhoven PJ, et al. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul;125(1):169-75.
- [2]. Gresnigt MS, et al. Neutrophil-Mediated Inhibition of Proinflammatory Cytokine Responses. The Journal of Immunology. 2012 Nov 15;189(10):4806-4815.
- [3]. Waki H, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6. [Content Brief]
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