344930-95-6
Chemical Structure
SSR69071
- CAS No.: 344930-95-6
- Formula:C27H32N4O7S
- Molecular Weight:556.63
IUPAC Name: 4-isopropyl-6-methoxy-2-(((4-oxo-9-(2-(piperidin-1-yl)ethoxy)-4H-pyrido[1,2-a]pyrimidin-2-yl)oxy)methyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
InChIKey: DRZXDZYWZSKFDL-UHFFFAOYSA-N
SMILES: O=C1C=C(OCN(C(C2=C3C=C(OC)C=C2C(C)C)=O)S3(=O)=O)N=C4N1C=CC=C4OCCN5CCCCC5
Biological Activity: SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury[1]. SSR69071 displays a higher affinity for human elastase (Ki=0.0168 nM) than for rat (Ki=3 nM), mouse (Ki=1.8 nM), and rabbit (Ki= 58 nM) elastases[2].
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SSR69071 | 98.4% | SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury. SSR69071 displays a higher affinity for human elastase (Ki=0.0168 nM) than for rat (Ki=3 nM), mouse (Ki=1.8 nM), and rabbit (Ki= 58 nM) elastases. | ||||||||||||||||||||
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- [1]. Jean-Pierre Bidouard, et al. SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur J Pharmacol. 2003 Feb 7;461(1):49-52. [Content Brief]
- [2]. Zoltan Kapui, et al. Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elast [Content Brief]
Keywords
