1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. DU125530

DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects.

For research use only. We do not sell to patients.

DU125530 Chemical Structure

DU125530 Chemical Structure

CAS No. : 161611-99-0

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Description

DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2].

IC50 & Target[1]

5-HT1A Receptor

0.7 nM (Ki)

5-HT1B Receptor

890 nM (Ki)

5-HT1C Receptor

1200 nM (Ki)

5-HT2A Receptor

240 nM (Ki)

5-HT2C Receptor

750 nM (Ki)

5-HT3 Receptor

1100 nM (Ki)

In Vivo

DU125530 (3 mg/kg; s.c.) reduces the reduction of 5-HT release induced by 8-OH-DPAT (HY-112061) in wild-type mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type mice[2]
Dosage: 3 mg/kg
Administration: S.c.
Result: Prevented the reduction of 5-HT release induced by 0.5 mg·kg−1 s.c. 8-OH-DPAT in WT mice, alone had no effect on the extracellular 5-HT concentration in mPFC of wild-type mice (WT) nor in 5-HT1A receptor knock-out mice (KO).
Clinical Trial
Molecular Weight

491.99

Formula

C23H26ClN3O5S

CAS No.
SMILES

O=C(C1=C2C=CC=C1)N(CCCCN3CCN(C4=C5OCCOC5=CC(Cl)=C4)CC3)S2(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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DU125530 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DU125530
Cat. No.:
HY-19283
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