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BT18 

Cat. No.: HY-111969
Handling Instructions

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.

For research use only. We do not sell to patients.

BT18 Chemical Structure

BT18 Chemical Structure

CAS No. : 924811-53-0

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Description

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].

In Vitro

BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].
BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].
BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1].

Western Blot Analysis[1]

Cell Line: MG87RET cell lines
Concentration: 50 μM
Incubation Time: 1, 5, 15, 45, 90 minutes
Result: Activated AKT and ERK1/2 in time-dependently.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

637.64

Formula

C₃₀H₃₁F₄N₃O₆S

CAS No.

924811-53-0

SMILES

O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=C(OC)C(OC)=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

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BT18
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HY-111969
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BT18

Cat. No.: HY-111969