1. Metabolic Enzyme/Protease
  2. Elastase

ZD-0892 

Cat. No.: HY-19254
Handling Instructions

ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

For research use only. We do not sell to patients.

ZD-0892 Chemical Structure

ZD-0892 Chemical Structure

CAS No. : 171964-73-1

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

IC50 & Target

Ki: 6.7 nM (Human neutrophil elastase), 200 nM (Human neutrophil elastase)[1]

In Vivo

ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis[1]. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0019 mL 10.0096 mL 20.0192 mL
5 mM 0.4004 mL 2.0019 mL 4.0038 mL
10 mM 0.2002 mL 1.0010 mL 2.0019 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1][2]

Rats[2]

Adult male Sprague-Dawley rats (250-300 g in body weight) are induced pulmonary hypertension. In addition to a group of untreated rats, the experimental groups include rats that receive twice-daily gavage tube feedings of ZD0892, at a dose of 240 mg/kg per day or vehicle (5% polyethylene glycol or dimethyl sulfoxide). Rats are examined after 7 days of treatment.

Mice[1]

DBA/2 male mice 8 weeks old is used. ZD0892 is given in a dose of 60 mg/kg or 120 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

499.52

Formula

C₂₄H₃₂F₃N₃O₅

CAS No.

171964-73-1

SMILES

CC(C)[[email protected]@H](C(N1[[email protected]](C(N[[email protected]](C(C(F)(F)F)=O)C(C)C)=O)CCC1)=O)NC(C2=CC=C(OC)C=C2)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ZD-0892
Cat. No.:
HY-19254
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ZD-0892

Cat. No.: HY-19254