1613621-55-8
Chemical Structure
CHF-6333 chloride
- CAS No.: 1613621-55-8
- Formula:C27H28ClF3N6O3
- Molecular Weight:577.00
InChIKey: BELHKGFRTGKJAB-GNAFDRTKSA-N
SMILES: COC(C([C@@H](C1=C(C=C(C=C1)C#N)CC[N+](C)(C)C)N23)=C(C)N(C4=CC(C(F)(F)F)=CC=C4)C2=NNC3=O)=O.[Cl-]
Biological Activity: CHF-6333 chloride is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF-6333 chloride retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 chloride exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 chloride can be used for the study of bronchiectasis (BE)[1].
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CHF-6333 chloride | CHF-6333 chloride is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF-6333 chloride retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 chloride exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 chloride can be used for the study of bronchiectasis (BE). | |||||||||||||||||||||
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Keywords
