Elastase
Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase. Elastase can not only cleave the important connective tissue protein elastin, but also facilitate the degradation of the extracellular matrix such as fibronectin; laminin; collagens III, IV, and VI; and proteoglycans.
Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.
All Product Categories
-
Elastase Related Products (107)
Related Products (107)
-
Elastase, Rat
0 ImagesCat. No.: HY-P2974AElastase, Rat (EC 3.4.21.35) is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta-barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together.
-
Suc-Ala-Pro-Ala-AMC
0 ImagesCat. No.: HY-P4362CAS No.: 88467-44-1Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase.
-
AZD-9819
0 ImagesCat. No.: HY-123791CAS No.: 956907-23-6AZD-9819 is a neutrophil elastase (HNE) inhibitor. AZD-9819 can be used to study chronic obstructive pulmonary disease.
-
Suc-AAP-Abu-pNA
0 ImagesCat. No.: HY-126785CAS No.: 108392-27-4Synonyms: Colorimetric Elastase SubstrateSuc-AAP-Abu-pNA (Colorimetric Elastase Substrate) is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,000 s-1 M-1 for porcine pancreatic elastase). Suc-AAP-Abu-pNA also promotes OPC migration.
-
(1'S,2'S)-1'-O-Methylvaginol
0 ImagesCat. No.: HY-N19660CAS No.: 1642784-96-0(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an elastase inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases.
-
Suc-Ala-Ala-Pro-Val-AMC
0 ImagesSuc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds.
-
Scyptolin B
0 ImagesCat. No.: HY-P11337CAS No.: 403479-63-0Scyptolin B, a cyclic depsipeptides, is a secondary metabolite. Scyptolin B can be isolated from axenic cultures of Scytonema hofmanni PCC 7110. Scyptolin B selective inhibits porcine pancreatic Elastase with an IC50 of 3.1 μg/mL.
-
Alvelestat tosylate
0 ImagesCat. No.: HY-15651ACAS No.: 1240425-05-1Synonyms: AZD9668 tosylateAlvelestat tosylate (AZD9668 tosylate) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat tosylate reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat tosylate restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat tosylate prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat tosylate inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat tosylate can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis.
-
L 659286
0 ImagesCat. No.: HY-118261CAS No.: 119742-06-2
-
Secologanoside (Standard)
0 ImagesCat. No.: HY-N6876RCAS No.: 59472-23-0Secologanoside (Standard) is the analytical standard of Secologanoside. This product is intended for research and analytical applications. Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts.
-
Alvelestat (Standard)
0 ImagesSynonyms: AZD9668 (Standard)Alvelestat (Standard) (AZD9668 (Standard)) is the analytical standard of Alvelestat (HY-15651). This product is intended for research and analytical applications. Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis.
-
Rhusflavanone
0 ImagesCat. No.: HY-N19905CAS No.: 53060-72-3Rhusflavanone is a biflavonoid found in the stamens of Mesua ferrea. Rhusflavanone IC50 values against elastase and tyrosinase are 10.6 and 14.3 μg/mL, respectively. Rhusflavanone inhibits the replication of influenza B virus, SARS-CoV-2, Measles virus and HSV-2, and suppresses the secretion of Salmonella T3SS effector proteins. Rhusflavanone inhibits the production of pro-inflammatory mediators and exerts cytotoxic effects on cancer cells. Rhusflavanone can be used in research related to colon cancer, breast cancer, cervical cancer, COVID-19, influenza B, measles, HSV-2 infection and Salmonella infection.
-
Alvelestat-13C,d3
0 ImagesCat. No.: HY-15651SSynonyms: AZD9668-13C,d3Alvelestat-13C,d3 (AZD9668-13C,d3) is the deuterated, 13C-labeled Alvelestat (HY-15651). Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis.
-
BAY-8040
0 ImagesCat. No.: HY-124051CAS No.: 1194453-23-0BAY-8040 is a pyrimidopyridazine derivative which has inhibitory activity against human neutrophil elastase (HNE). BAY-8040 decreases cardiac remodeling and ameliorates cardiac function in a Monocrotaline (HY-N0750)-induced rat model for pulmonary arterial hypertension. BAY-8040 is promising for research of inflammatory pathologies and cardiopulmonary pathologies.
-
Alvelestat hydrochloride
0 ImagesCat. No.: HY-15651BCAS No.: 1240425-11-9Synonyms: AZD9668 hydrochlorideAlvelestat hydrochloride (AZD9668 hydrochloride) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat hydrochloride reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat hydrochloride restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat hydrochloride prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat hydrochloride inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat hydrochloride can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis.
-
LasB-IN-1
0 ImagesCat. No.: HY-163030LasB-IN-1 (compound 5f) is a potent and orally active inhibitor of LasB (IC50 = 8.7 μM). LasB-IN-1 effectively attenuates elastase production and biofilm formation by P. aeruginosa while alleviating the inflammatory response through downregulating MAPK and NF-κB pathways. LasB-IN-1 is potential to be a novel anti-infective candidate against drug-resistant infections.
-
BAY-678 (Standard)
0 ImagesCat. No.: HY-111457ARCAS No.: 675103-36-3BAY-678 (Standard) is the analytical standard of BAY-678 (HY-111457A). This product is intended for research and analytical applications. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
-
HLE-IN-1
0 ImagesCat. No.: HY-138570CAS No.: 13947-21-2
-
KLK7 modulator-1
0 ImagesCat. No.: HY-186007CAS No.: 342594-95-0KLK7 modulator-1 is a KLK7 modulator.
-
Nostopeptin B
0 ImagesCat. No.: HY-P2033CAS No.: 185980-89-6Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against elastase and chymotrypsin.
