Elastase
Elastase is a group of serine proteases that include the macrophage elastase, the fibroblast elastase, the neutrophil elastase, and the pancreatic elastase. Elastase can not only cleave the important connective tissue protein elastin, but also facilitate the degradation of the extracellular matrix such as fibronectin; laminin; collagens III, IV, and VI; and proteoglycans.
Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.
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Elastase Related Products (107)
Related Products (107)
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MeOSuc-Ala-Ala-Pro-Met-AMC
0 ImagesCat. No.: HY-P4346CAS No.: 201853-55-6MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases.
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L-680833
0 ImagesCat. No.: HY-120876CAS No.: 127063-08-5
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MeOSuc-AAPV-AFC
0 ImagesCat. No.: HY-P5374CAS No.: 125791-90-4MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)
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(6-Rac)-Kirenol
0 ImagesCat. No.: HY-N0559ACAS No.: 1622876-96-3(6-Rac)-Kirenol is an ent-pimarane-type diterpenoid. (6-Rac)-Kirenol inhibits the production of superoxide anions in activated human neutrophils. (6-Rac)-Kirenol inhibits the release of elastase from activated human neutrophils.
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Elafin(human)
0 ImagesCat. No.: HY-P5459Purity: 98.35%Elafin(human) is a serine protease inhibitory peptide that potently inhibits human neutrophil elastase (HLE) and human proteinase 3 (PR3). Elafin(human) forms a substrate-like, competitive and fully reversible complex with HLE at a 1:1 stoichiometric ratio, with a Ki of 0.17 nM. Elafin(human) inhibits PR3-mediated degradation of elastin-FITC, with an IC50 of 9.5 nM. Elafin(human) can be used in studies of neutrophil serine proteases, elastin degradation and inflammation-related tissue damage
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CHF-6333 chloride
0 ImagesCat. No.: HY-182465CAS No.: 1613621-55-8CHF-6333 chloride is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF-6333 chloride retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF-6333 chloride exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 chloride can be used for the study of bronchiectasis (BE).
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Ala-Ala-Pro-Val-chloromethylketone
0 ImagesCat. No.: HY-P3648CAS No.: 90105-47-8Synonyms: AAPV-CMKAla-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases.
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Antibiofilm agent-22
0 ImagesCat. No.: HY-183361Antibiofilm agent-22 is an FpvA receptor-targeting antibacterial agent. Antibiofilm agent-22 chelates iron, disrupts las, pqs, and rhl pathways, reduces elastase, pyocyanin, and rhamnolipid production, and induces bacterial iron starvation. Antibiofilm agent-22 can be used for the research of Pseudomonas aeruginosa infection.
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CHF-6333 xinafoate
0 ImagesCat. No.: HY-179566ACAS No.: 3071964-44-5CHF-6333 xinafoate is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF6333 xinafoate retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF6333 xinafoate exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 xinafoate can be used for the study of bronchiectasis (BE).
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XDS-23
0 ImagesCat. No.: HY-179389XDS-23 is a selective biofilm inhibitor with an IC50 of 1.26 µM against Pseudomonas aeruginosa. XDS-23 exerts a dual inhibitory effect on the LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs). XDS-23 suppress the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides. XDS-23 exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo models, while maintaining a favorable safety profile. XDS-23 can be employed for research in combating biofilm-mediated drug-resistant P. aeruginosa infections.
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PV-DPD-19
0 ImagesCat. No.: HY-182942CAS No.: 3112321-20-4PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with Staphylococcus aureus, PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa. PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa (MBIC50 = 27 μg/mL) and Staphylococcus aureus (MBIC50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models.
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Endosidin1
0 ImagesCat. No.: HY-N19297CAS No.: 57672-91-0Synonyms: PrieurianinEndosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC50 >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer.\n
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MeO-Suc-Ala-Ala-Pro-Ala-CMK
0 ImagesCat. No.: HY-136705CAS No.: 111682-13-4Synonyms: MSACKMeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE), with an IC50 of 20.3 μM. MeO-Suc-Ala-Ala-Pro-Ala-CMK can inhibit the hydrolysis of substrates such as elastin in lung tissue by HNE. MeO-Suc-Ala-Ala-Pro-Ala-CMK can be used in the research of related diseases such as chronic obstructive pulmonary disease (COPD).
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ICI-200880
0 ImagesCat. No.: HY-106293CAS No.: 105080-50-0ICI-200880 is a potent, selective and reversible human neutrophil elastase (HNE) inhibitor. ICI-200880 is promising for research of inflammatory lung diseases related to neutrophil elastase, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF).
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Eglin c (60-63)
0 ImagesCat. No.: HY-P11787CAS No.: 122299-14-3Eglin c (60-63) is a selective Elastase inhibitor, with a Ki value of 2.3e-3 M against human leukocyte hElastase and a Ki value of 4.8e-3 M against porcine pancreatic Elastase. Eglin c (60-63) can be used in research related to rheumatoid arthritis.
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Pyracrenic acid
0 ImagesCat. No.: HY-130294CAS No.: 80832-44-6Pyracrenic acid is an elastase inhibitor (IC50 = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity.
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Tyrosinase/elastase-IN-1
0 ImagesCat. No.: HY-143206Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.
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Phochinenin K
0 ImagesCat. No.: HY-N17881CAS No.: 1070883-79-2Phochinenin K is a 9,10-dihydrophenanthrene derivative present in the rhizomes of Bletilla formosana. Phochinenin K exhibits anti-inflammatory activity and can be used in the study of inflammatory diseases.
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Neutrophil elastase inhibitor 4
0 ImagesCat. No.: HY-155231Neutrophil elastase inhibitor 4 is a human neutrophil elastase (HNE) inhibitor with an IC50 of 21.78 nM and a Ki of 8.04 nM. Neutrophil elastase inhibitor 4 induces G2/M cell cycle arrest and apoptosis. Neutrophil elastase inhibitor 4 is applicable to research related to breast cancer, multiple myeloma and non-small cell lung cancer.
