Neutrophil elastase inhibitor 4
Based on 1 publication(s) in Google Scholar
Neutrophil elastase inhibitor 4 is a human neutrophil elastase (HNE) inhibitor with an IC50 of 21.78 nM and a Ki of 8.04 nM. Neutrophil elastase inhibitor 4 induces G2/M cell cycle arrest and apoptosis. Neutrophil elastase inhibitor 4 is applicable to research related to breast cancer, multiple myeloma and non-small cell lung cancer.
For research use only. We do not sell to patients.
- Formula: C20H21N3O5
- Molecular Weight:383.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
42.30 nM human neutrophil elastase[1]
Neutrophil elastase inhibitor 4 (Compound 4f) (72 h) potently inhibits the proliferation of T47D, RPMI 8226 and A549 cancer cells with IC50 values of 21.25, 34.17 and 29.93 µM, and exhibits high selectivity toward normal human skin fibroblasts[1].
Neutrophil elastase inhibitor 4 (5-40 µM; 48 h) induces G2/M cell cycle arrest in T47D breast cancer cells and triggers apoptotic cell death in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human T47D breast carcinoma cells
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Concentration:5, 10, 20, and 40 µM
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Incubation Time:48 h
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Result:Induced concentration-dependent apoptosis: the percentage of apoptotic cells increased from 2.17% (control) to 3.99%, 13.99%, 21.54%, and 34.49% at 5, 10, 20, and 40 µM, respectively.
Necrosis also increased at 20 and 40 µM (to 10.52% and 9.77%, respectively, from 2.19% control).
Was over four times more potent at inducing apoptosis than lenalidomide at 20 µM.
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Cell Line:human T47D breast carcinoma cells
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Concentration:5, 10, 20, and 40 µM
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Incubation Time:48 h
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Result:Induced concentration-dependent G2/M phase arrest: at 5, 10, 20, and 40 µM, the percentage of cells in G2 phase increased from 15.77% (control) to 17.83%, 24.68%, 26.11%, and 22.82%, respectively, while G1 phase cell numbers decreased.
Chemical Information
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Molecular Weight 383.40
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Formula C20H21N3O5
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SMILES
O=C(C(N(CC1=C2C=CC=C1N3C(C(CC)(CC)C3=O)=O)C2=O)CC4)NC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neutrophil elastase inhibitor 4 Related Classifications
HY-155231 Related Classifications
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