Endosidin1  (Synonyms: Prieurianin)

Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC₅₀ >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer^[1].\n

Endosidin1 (3 days) exhibits mild cytotoxicity against HEp-2 laryngeal cancer cells with an ED₅₀ of 16.77 μg/mL, but shows no significant cytotoxicity against Hep-G2, A549 or MCF-7 cells^[1].
Endosidin1 inhibits superoxide anion production in FMLP/CB-stimulated neutrophils by 49.20%, with an IC₅₀ >10 μg/mL^[1].
Endosidin1 (10 μg/mL) inhibits elastase release from neutrophils stimulated by FMLP/CB, with an inhibition rate of 39.36% at the concentration of 10 μg/mL and an IC₅₀ >10 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

762.79

C₃₈H₅₀O₁₆

57672-91-0

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• [1]. Lin CJ, et al. Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya. Molecules. 2016;21(9):1167. Published 2016 Sep 2.