3071964-44-5
3071964-44-5
Chemical Structure
CHF-6333 xinafoate
- CAS No.: 3071964-44-5
- Formula:C38H35F3N6O6
- Molecular Weight:728.72
InChIKey: YHTRTIHMDPAQKX-GNAFDRTKSA-N
SMILES: FC(F)(C1=CC=CC(N2C(C)=C([C@H](N3C2=NNC3=O)C4=C(C=C(C=C4)C#N)CC[N+](C)(C)C)C(OC)=O)=C1)F.OC5=C(C=CC6=C5C=CC=C6)C([O-])=O
Biological Activity: CHF-6333 xinafoate is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF6333 xinafoate retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF6333 xinafoate exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 xinafoate can be used for the study of bronchiectasis (BE)[1].
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CHF-6333 xinafoate | CHF-6333 xinafoate is a neutrophil elastase (NE) inhibitor (IC50 = 0.21 nM; KD = 0.16 nM). CHF6333 xinafoate retains its activity in both human (IC50 = 0.22 nM) and rat (IC50 = 3.63 nM) proteases. CHF6333 xinafoate exhibits inhibitory activity against Proteinase 3 (IC50 = 22 nM). CHF-6333 xinafoate can be used for the study of bronchiectasis (BE). | |||||||||||||||||||||
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