(1'S,2'S)-1'-O-Methylvaginol
(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an elastase inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1642784-96-0
- Formula: C15H16O5
- Molecular Weight:276.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | Survival |
100.24 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
|
[PMID: 28571822] |
| Hep 3B2 | Survival |
112.3 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
|
[PMID: 28571822] |
| Hep 3B2 | Survival |
69.21 %
Compound: 3
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Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
|
[PMID: 28571822] |
| Hep 3B2 | Survival |
87.06 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
|
[PMID: 28571822] |
| NIH3T3 | Survival |
118.12 %
Compound: 3
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Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
|
[PMID: 28571822] |
| NIH3T3 | Survival |
128.66 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
|
[PMID: 28571822] |
| NIH3T3 | Survival |
69.02 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
|
[PMID: 28571822] |
| NIH3T3 | Survival |
93.01 %
Compound: 3
|
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
|
[PMID: 28571822] |
In Vitro
(1'S,2'S)-1'-O-Methylvaginol (10 μg/mL; 5 min) inhibits fMLP/CB-induced superoxide anion generation by human neutrophils by 11.99%[1].
(1'S,2'S)-1'-O-Methylvaginol (10 μg/mL; 5 min) inhibits fMLP/CB-induced elastase release by human neutrophils by 6.42%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1642784-96-0
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Molecular Weight 276.28
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Formula C15H16O5
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SMILES
CO[C@H]1C2=C(O[C@@H]1C(C)(O)C)C=CC(C=C3)=C2OC3=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(1'S,2'S)-1'-O-Methylvaginol Related Classifications
HY-N19660 Related Classifications
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