2. Metabolic Enzyme/Protease
  3. Elastase
  4. (1'S,2'S)-1'-O-Methylvaginol

(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an elastase inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases.

For research use only. We do not sell to patients.

(1'S,2'S)-1'-O-Methylvaginol

(1'S,2'S)-1'-O-Methylvaginol Chemical Structure

CAS No. : 1642784-96-0

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(1'S,2'S)-1'-O-Methylvaginol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an elastase inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases[1].

Cellular Effect
Cell Line Type Value Description References
Hep 3B2 Survival
100.24 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
[PMID: 28571822]
Hep 3B2 Survival
112.3 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
[PMID: 28571822]
Hep 3B2 Survival
69.21 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
[PMID: 28571822]
Hep 3B2 Survival
87.06 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
Cytoprotective activity against GOX-induced oxidative stress in human Hep3B cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 41.51 +/- 1.39%)
[PMID: 28571822]
NIH3T3 Survival
118.12 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 10 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
[PMID: 28571822]
NIH3T3 Survival
128.66 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 100 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
[PMID: 28571822]
NIH3T3 Survival
69.02 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 0.1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
[PMID: 28571822]
NIH3T3 Survival
93.01 %
Compound: 3
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
Cytoprotective activity against GOX-induced oxidative stress in mouse NIH/3T3 cells assessed as cell survival at 1 uM treated for 5 hrs with 15 mU/ml GOX challenge by MTT assay (Rvb = 42.71 +/- 2.10%)
[PMID: 28571822]
In Vitro

(1'S,2'S)-1'-O-Methylvaginol (10 μg/mL; 5 min) inhibits fMLP/CB-induced superoxide anion generation by human neutrophils by 11.99%[1].
(1'S,2'S)-1'-O-Methylvaginol (10 μg/mL; 5 min) inhibits fMLP/CB-induced elastase release by human neutrophils by 6.42%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(1'S,2'S)-1'-O-Methylvaginol Related Antibodies
Molecular Weight

276.28

Formula

C15H16O5
CAS No.
SMILES

CO[C@H]1C2=C(O[C@@H]1C(C)(O)C)C=CC(C=C3)=C2OC3=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(1'S,2'S)-1'-O-Methylvaginol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1'S,2'S)-1'-O-Methylvaginol1642784-96-0ElastasecoumarinfMLP/CBhuman neutrophilssuperoxide anion generationelastase releaseCnidium monnieriInhibitorinhibitorinhibit

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(1'S,2'S)-1'-O-Methylvaginol
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