2. Apoptosis
  3. IAP Apoptosis
  4. HM90822

HM90822 is an orally active IAP antagonist. HM90822 induces ubiquitination and proteasome-dependent degradation of XIAP, cIAP1 and cIAP2 in sensitive pancreatic cancer cells. HM90822 induces Apoptotic cell death. HM90822 inhibits tumor growth in Panc-1 pancreatic cancer xenograft and orthotopic mouse models. HM90822 can be used for the research of pancreatic cancer.

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HM90822

HM90822 Chemical Structure

CAS No. : 1363145-46-3

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HM90822 Related Antibodies

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cIAP cIAP-1 cIAP-2 XIAP

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Description

HM90822 is an orally active IAP antagonist. HM90822 induces ubiquitination and proteasome-dependent degradation of XIAP, cIAP1 and cIAP2 in sensitive pancreatic cancer cells. HM90822 induces Apoptotic cell death. HM90822 inhibits tumor growth in Panc-1 pancreatic cancer xenograft and orthotopic mouse models. HM90822 can be used for the research of pancreatic cancer[1].

IC50 & Target[1]

XIAP

 

cIAP-1

 

cIAP2

 

In Vitro

HM90822 (72 h) induces dose-dependent cell death in human pancreatic cancer cell lines, with IC50 values of 0.142 μM (BxPC-3), 0.164 μM (Panc03.27), 0.324 μM (Panc-1), 5.3 μM (PL45), and 6.7 μM (Capan-1) after 72 h incubation, while Panc08.13, MiaPaCa-2, Capan-2, and AsPC-1 cells are resistant with IC50 values above 37 μM[1].
HM90822 (0.3-10 μM; 18 h) induces dose-dependent reduction of XIAP and cIAP1 protein expression in sensitive BxPC-3 and Panc-1 human pancreatic cancer cell lines after 18 h incubation, but has no effect on these proteins in resistant MiaPaCa-2 and Capan-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HM90822 Related Antibodies
In Vivo

HM90822 (150 mg/kg; p.o.; daily; 14 days) reduces the volume of subcutaneous Panc-1 xenografts in female Balb/c nude mice without altering their body weight[1].
HM90822 (50-200 mg/kg; p.o.; once daily; for 14 consecutive days) exerts anti-tumor effects in female Balb/c nude mice with Panc-1 orthotopic xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude (female)[1]
Dosage: 150 mg/kg
Administration: p.o.; daily; 14 days
Result: Reduced tumor size compared to controls.
Did not alter body weight compared to controls.
Animal Model: Balb/c nude (female)[1]
Dosage: 50 mg/kg; 100 mg/kg; 200 mg/kg
Administration: p.o.; daily; 14 days
Result: Significantly reduced intrapancreatic tumor weight at all tested doses compared to controls (P<0.05).
Reduced body weights by approximately 10-20% compared to controls.
Molecular Weight

632.11

Formula

C30H36ClF2N7O4
CAS No.
SMILES

N(C=1C2=C(C=C(OC)C(NC(=O)[C@H]3N(C([C@@H](NC([C@@H](NC)C)=O)[C@](C)(C)C)=O)CCC3)=C2)N=CN1)C4=C(F)C(Cl)=C(F)C=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HM90822 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HM908221363145-46-3HM 90822HM-90822IAPApoptosiscIAP2AKTubiquitinationproteasome-dependent degradationXIAPcIAP1Panc-1BxPC-3human pancreatic cancer cellscaspase-dependent apoptotic cell deathInhibitorinhibitorinhibit

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